TESSA JOWELL BRAIN MATRIX PLATFORM STUDY: PRELIMINARY ANALYSIS OF THE PRIMARY FEASIBILITY & PROCESS-CENTRED OBJECTIVE (2024)

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Volume 25 Issue Supplement_3 October 2023

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Colin Watts

University of Birmingham

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Amit Patel

Cancer Research UK Clinical Trials Unit, University of Birmingham

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Joshua Savage

Cancer Research UK Clinical Trials Unit, University of Birmingham

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Olaf Ansorge

University of Oxford

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Victoria Wykes

University of Birmingham

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Yvonne Wallis

Birmingham Women’s and Children’s NHS Foundation Trust

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Rowena Sharpe

Cancer Research UK Clinical Trials Unit, University of Birmingham

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Rhys Mant

Cancer Research UK Clinical Trials Unit, University of Birmingham

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Hannah Brooks

University of Oxford

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Susan Short

Leeds Teaching Hospitals NHS Trust

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Keyoumars Ashkan

King’s College London

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Paul Brennan

University of Edinburgh

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Anthony Chalmers

University of Glasgow

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Stuart Smith

Nottingham University Hospitals NHS Trust

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Michael Jenkinson

The Walton Centre NHS Foundation Trust

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Catherine McBain

The Christie NHS Foundation Trust

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Adam Waldman

University of Edinburgh

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Gerard Thompson

University of Edinburgh

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Lucinda Billingham

Cancer Research UK Clinical Trials Unit, University of Birmingham

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Neuro-Oncology, Volume 25, Issue Supplement_3, October 2023, Pages iii8–iii9, https://doi.org/10.1093/neuonc/noad147.035

Published:

16 September 2023

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    Colin Watts, Amit Patel, Joshua Savage, Olaf Ansorge, Victoria Wykes, Yvonne Wallis, Rowena Sharpe, Rhys Mant, Hannah Brooks, Susan Short, Keyoumars Ashkan, Paul Brennan, Anthony Chalmers, Stuart Smith, Michael Jenkinson, Catherine McBain, Adam Waldman, Gerard Thompson, Lucinda Billingham, TESSA JOWELL BRAIN MATRIX PLATFORM STUDY: PRELIMINARY ANALYSIS OF THE PRIMARY FEASIBILITY & PROCESS-CENTRED OBJECTIVE, Neuro-Oncology, Volume 25, Issue Supplement_3, October 2023, Pages iii8–iii9, https://doi.org/10.1093/neuonc/noad147.035

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Abstract

AIMS

The Tessa Jowell BRAIN MATRIX (ISRCTN14218060) is an ongoing platform study, collecting disease, treatment, and outcome data prospectively in glioma patients, across nine UK hospitals. We report a preliminary analysis of the primary feasibility and process-centred objectives.

METHOD

Primary Objective: Test the feasibility of establishing an integrated histological-molecular diagnosis using Whole Genome Sequencing (WGS) and Epigenomic Classification (EC) (‘Heidelberg Classifier’) data in NHS practice within 28 days.

Primary Outcome: Time (from surgery) to integrated histological–molecular diagnosis (TTMD) using WGS and EC.

Secondary Outcome: Time to completion of each node (stage) of the tissue and imaging pathway.

RESULTS

Data snapshot on 23-Feb-2023 confirmed 250 patients recruited. Nine nodes along the tissue & imaging pathway were defined. Twenty-one patients had completed the pathway and time to each node was calculated. Median time to complete the pathway was 404 days (range 124-653). There was a trend of improvement in TTMD in recently recruited patients.

CONCLUSIONS

The patient pathway from surgery to clinical feedback through a Genomic Tumour Advisory Board (GTAB) utilises NHS-accredited pathways and protocols. Delays inherent in the pathway emphasise the urgent need for infrastructure and operational delivery improvements of the NHS Genomic Medicine Service for brain cancer patients as the current timeframe is not clinically relevant for informing patient care. These data also highlight geographical inequality in accessing genomic medicine within England, across the seven Genomic Laboratory Hubs, and the devolved nations. Detailed analysis of the delays at each node will identify opportunities and solutions to inform discussions with the NHS and Genomics England.

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© The Author(s) 2023. Published by Oxford University Press on behalf of the Society for Neuro-Oncology. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com

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Topic:

  • feedback
  • genome
  • genomics
  • glioma
  • objective (goal)
  • molecular diagnostic techniques
  • surgical procedures, operative
  • brain
  • diagnosis
  • diagnostic imaging
  • neoplasms
  • surgery specialty
  • genomic medicine
  • national health service (uk)
  • primary outcome measure
  • whole genome sequencing
  • epigenomics
  • malignant brain neoplasms

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